Diphosphates are the acidity regulators the food industry lists as E450. In our table they are high risk: they take 30 points off the additive subscore, which is worth a third of a product's score (about 10 of the 100).
- The key finding, from EFSA: Group ADI of 40 mg/kg bw per day expressed as phosphorus; dietary exposure may exceed the ADI for infants, toddlers and children at MEAN consumption, and for adolescents with high phosphate diets (EFSA Journal 2019;17(6):5674, doi:10.2903/j.efsa.2019.5674, Re-evaluation of phosphoric acid, phosphates, di-, tri- and polyphosphates (E 338 to 341, E 343, E 450 to 452))
- Flagged for young children. Set only where EFSA’s own exposure assessment shows toddlers or children exceeding or approaching the ADI, or where a regulator used explicitly child-specific language. It is already in our top class, so the flag cannot move it higher.
- Where you meet it. They turn up in 238 of the 10,000 packaged foods scanned most on Open Food Facts, most often in cookies, cakes and cheese. Nine in ten of those foods are sold in Europe (counted 26 Sep 2026).
- 2 citations from EFSA, each one below.
What Diphosphates do to a score
A packaged food's additive subscore starts at 100 and loses points for each additive on the label; that subscore is a third of the final score. Diphosphates take 30 points off the additive subscore, which is worth a third of a product's score (about 10 of the 100). Scan the pack in Sito and the score you get is the one for your own child's age, with this additive named in the reasons. How we score has the whole method.
See what is in your own cupboard
Scan a packaged food and Sito names the additives in it, then scores the product out of 100 for your child's age.
What the sources found
Every classification in our table comes from the citations below, and nothing else. Each finding is our one-line summary of what the source concluded, with the source and reference beside it.
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EFSA
Journal 2019;17(6):5674 — doi:10.2903/j.efsa.2019.5674, Re-evaluation of phosphoric acid–phosphates, di-, tri- and polyphosphates (E 338–341, E 343, E 450–452)
Group ADI of 40 mg/kg bw per day expressed as phosphorus; dietary exposure may exceed the ADI for infants, toddlers and children at MEAN consumption, and for adolescents with high phosphate diets. -
EFSA
news release 190612 — 'EFSA issues new advice on phosphates', 12 June 2019
ADI does not apply to people with moderate-to-severe reduced kidney function; EFSA recommends numerical maximum levels replace quantum satis in supplements for ages 3+.
Why this class
IARC Group 1 or 2A with a dietary exposure route; or EFSA has withdrawn or negated a safety conclusion; or EFSA’s own exposure assessment finds a child age group exceeding the ADI at mean intake; or the substance is banned or formally being phased out for food use by the EU, by the US FDA, or under a US state law.
Our confidence in this row's classification is high. Medium or low does not mean the evidence is weak; it means something about the row is still being pinned down, usually a regulatory status confirmed from one source rather than two.
Questions parents ask
Are Diphosphates (E450) safe for kids?
High risk. In Sito it takes 30 points off the additive subscore, which is worth a third of a product's score (about 10 of the 100). It is flagged for young children, and it is already in our top class, so the flag cannot move it higher. The finding we rely on: Group ADI of 40 mg/kg bw per day expressed as phosphorus; dietary exposure may exceed the ADI for infants, toddlers and children at MEAN consumption, and for adolescents with high phosphate diets (EFSA Journal 2019;17(6):5674, doi:10.2903/j.efsa.2019.5674, Re-evaluation of phosphoric acid, phosphates, di-, tri- and polyphosphates (E 338 to 341, E 343, E 450 to 452)).
What is E450?
E450 is the E number for Diphosphates, which our table lists as an acidity regulator. Open Food Facts tags it en:e450.
Next to it on the label
The E numbers either side of E450 in our table, then the closest acidity regulators by number.
- Glycerol esters of wood rosin (E445), no risk identified
- Triphosphates (E451), high risk, flagged for young children
- Polyphosphates (E452), high risk, flagged for young children
- Sodium carbonates (E500), no risk identified
- Potassium carbonates (E501), no risk identified
- Carbonates (E502), no risk identified